Propofol
(pro´pah-fol) a short-acting sedative and hypnotic used as a general anesthetic and adjunct to anesthesia, administered intravenously. Its uses include the induction and maintenance of general anesthesia, sedation for mechanically ventilated adults, and procedural sedation.
Chemically, propofol is unrelated to barbiturates, and has largely replaced sodium thiopental (Pentothal) for induction of anesthesia as recovery from propofol is more rapid and “clear” as compared to thiopental. Propofol is not considered an analgesic, so opioids such as fentanyl may be combined with propofol to alleviate pain. Due to its amnestic effects and appearance as a white liquid, propofol has been dubbed “milk of amnesia” by medical professionals.
Propofol has not yet been “scheduled” by the FDA, meaning it is not considered a “controlled substance”. A “controlled substance” is defined as a drug which has been declared by federal or state law to be illegal for sale or use, but may be dispensed under a physician’s prescription.
For IV Administration:
Strict aseptic technique must always be maintained during handling. Diprivan Injectable Emulsion is a single-use parenteral product which contains 0.005% disodium edetate to inhibit the rate of growth of microorganisms, for up to 12 hours, in the event of accidental extrinsic contamination. However, Diprivan Injectable Emulsion can still support the growth of microorganisms, as it is not an antimicrobially preserved product under USP standards. Accordingly, strict aseptic technique must still be adhered to. Do not use if contamination is suspected. Discard unused portions as directed within the required time limits. There have been reports in which failure to use aseptic technique when handling Diprivan Injectable Emulsion was associated with microbial contamination of the product and with fever, infection/sepsis, other life-threatening illness, and/or death.[1]
Propofol (aka Diprivan): 25 milligrams, diluted with Lidocaine aka Xlyocaine, administered intravenously at 10:40 a.m.
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